Our Adaptive Model Empowers

Adaptive is a systematic process for combining management, research, and monitoring, as a means of changing practices so that credible information is gained and future activities are modified by the prior experience.

This requires (1) real-time knowledge of a range of study parameters, (2) converting data to knowledge, and (3) the ability to act on information.

Adaptive Results:

Entire study is accelerated.
Cost is minimized.
Fruitless and wasteful arms are pruned.
Patient exposure to ineffective or less safe treatments is reduced.
Strategic decision-making becomes the focus.
Time between studies is reduced.

For 18 years, we have developed and perfected the tools and processes for managing studies the adaptive way – an unprecedented amount of information that enables tight control and benefit from continuous decision-making power that shortens timelines and reduces costs.

The value of this approach is reflected by our performance metrics which are significantly better than industry standards, and bottom-line financial performance, including return on investment and net present value measurements for drugs under development.

Make Timely and Strategic Decisions

Our tools and processes quickly transform data into knowledge giving you the ability to make timelier, better-informed, study-optimizing decisions.

Adaptive Advantages:

Strategic

A variety of techniques used to ensure efficiency including:

Pruning arms
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Pruning arms during first dose finding
Sample size reassessment
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Sample size reassessments, based on actual data rather than estimates
Rolling directly into phase III
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Rolling directly into phase III eliminating the study gap of 6-12 months
Switching from non-inferiority to superiority
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Switching from non-inferiority to superiority based on findings and ability to resize
Flexible randomization, blocking and adaptive techniques
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Flexible randomization, using our web-based system and enabling stratification, blocking, and adaptive techniques such as play-the-winner and Bayesian approaches;

Tactical

Monitoring a range of performance indices to adjust and allocate resources most effectively, including:

Enrollment
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Continuous tracking allows strategies to be refined, lessons to be broadly disseminated
Assessing site performance
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Enables corrective actions faster and without need to visit sites
Tracking site and study performance measures
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Tracking site and study performance measures such as query rates, response times, in real time
Allocating monitoring resources
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Allocation of monitoring resources based on where help is more needed
Reducing or eliminating of source data verification
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Reduction or elimination of source data verification with use of our SmartPen, which eases site work and can be used as source

Exercise Tight Control

You will benefit from tighter management based upon superior information, insight and the power to act rather than wonder and drift until all data is collected.

Reduce Expenses

Because you'll have the ability to accelerate entire programs, you'll not only finish each study faster, you'll experience substantial savings in both time and cost.